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Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review.

Kaja TrohaDomen VozelMatevž ArkoApolonija Bedina ZavecDrago DolinarMatej HočevarZala JanMatic KisovecBoštjan KocjančičLjubiša PađenManca PajničSamo PeničAnna RomoloNeža ReparVesna SpasovskiNejc SteinerVid ŠuštarAles IgličDamjana DrobneKsenija KogejSaba BattelinoVeronika Kralj-Iglič
Published in: International journal of molecular sciences (2023)
The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.
Keyphrases
  • bone marrow
  • cell therapy
  • platelet rich plasma
  • healthcare
  • stem cells
  • peripheral blood
  • quality improvement
  • mesenchymal stem cells
  • risk assessment
  • mass spectrometry
  • energy transfer
  • red blood cell