Dimethyl Malonate Protects the Lung in a Murine Model of Acute Respiratory Distress Syndrome.

Sharven TaghaviAlexandra CampbellDavid EngelhardtJuan DuchesneFarhana ShaheenDerek PociaskJay KollsOlan Jackson-Weaver

Published in: The journal of trauma and acute care surgery (2023)

DMM reduces lung inflammation and capillary leak in ARDS. This may be mediated by protection of the EGX and inhibition of MCP-1 and ICAM-1. DMM may be a novel therapeutic for ARDS.

Keyphrases

acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
oxidative stress