G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.

Conghui LiZhinang YinRuijing XiaoBeili HuangYali CuiHonghong WangYing XiangLingrui WangLingyu LeiJiaqin YeTianyu LiYouquan ZhongFangteng GuoYuchen XiaPingping FangKai-Wei Liang

Published in: Genome biology (2022)

These studies demonstrate that G4 functions as a sensor for natural porphyrin metabolites in cells, revealing a G4-dependent mechanism for metabolic regulation of gene transcription and chromatin landscapes, which will deepen our knowledge of G4 biology and the contribution of cellular metabolites to gene regulation.

Keyphrases

genome wide
transcription factor
ms ms
genome wide identification
photodynamic therapy
gene expression
dna damage
copy number
induced apoptosis
dna methylation
healthcare
metal organic framework
cell cycle arrest
cell death
oxidative stress
energy transfer
endoplasmic reticulum stress
electron transfer
case control