Exosomal miRNA-215-5p Derived from Adipose-Derived Stem Cells Attenuates Epithelial-Mesenchymal Transition of Podocytes by Inhibiting ZEB2.

Juan Ji Yunguang Wang Li Zhao Wenli Zou Mingming Tan Qiang He

Published in: BioMed research international (2020)

ADSCs-Exo has the protective effect on HG-evoked EMT progression of podocytes thru a mechanism involving ZEB2. Potentially, the ADSCs-Exo preparation is a useful therapeutic strategy for improving podocyte dysfunction and DN symptoms clinically.

Keyphrases

epithelial mesenchymal transition
high glucose
diabetic nephropathy
signaling pathway
endothelial cells
transforming growth factor
oxidative stress
fluorescent probe
wound healing
molecularly imprinted
sleep quality
living cells
aqueous solution
mass spectrometry