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Predictive factors for focal disease in human brucellosis, an observational cohort study.

Halima K Dabaja-YounisMenas AtariehMichal PaulElias NasrallahYuval GeffenImad KassisNesrin Ghanem-Zoubi
Published in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2022)
This retrospective cohort study aimed to identify predictors for focal disease in human brucellosis. The study included patients with brucellosis diagnosed between January 2000 and December 2021. Overall, 247 patients were identified. Focal disease was diagnosed in 64 (25.9%) patients. The most common focal infection was bone and joint in 56 patients (23.4%). Disease duration > 14 days was significantly associated with focal illness [OR = 2.2 (1.08-4.47), p = 0.030], although febrile illness was inversely associated with focal illness this did not reach statistical significance [OR = 0.46 (0.21-1.00), p = 0.050]. Focal brucellosis should be suspected in patients with prolonged illness.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • endothelial cells
  • prognostic factors
  • peritoneal dialysis
  • pulmonary embolism
  • patient reported outcomes