Temporal trends, risk factors and outcomes of infections due to extended-spectrum β-lactamase producing Enterobacterales in Swiss solid organ transplant recipients between 2012 and 2018.

Philipp P KohlerAline WolfensbergerSusanne StampfAndreas BrönnimannKatia BoggianChristian van DeldenMelody FavreCédric HirzelNina KhannaStefan P KusterOriol ManuelDionysios NeofytosSilvio RagozzinoPeter W SchreiberLaura WaltiNicolas J Muellernull null

Published in: Antimicrobial resistance and infection control (2021)

In Swiss SOT-recipients, proportion of infections with ESBL-producing non-E. coli Enterobacterales increased in recent years. Antibiotic pre-treatment represents a risk factor for ESBL-E. Improving appropriateness of empiric antibiotic treatment might be an important measure to reduce unfavourable outcome, which was observed in almost half of SOT-recipients with ESBL-E infections.

Keyphrases

escherichia coli
risk factors
klebsiella pneumoniae
type diabetes
combination therapy
adipose tissue
kidney transplantation
urinary tract infection
weight loss