Targeted Brain Tumor Radiotherapy Using an Auger Emitter.

Giacomo Pirovano Stephen A Jannetti Lukas Michael CarterAhmad SadiqueSusanne KossatzNavjot GuruPaula Demétrio De Souza FrançaMasatomo MaedaBrian M ZeglisJason S LewisJohn L HummThomas Reiner

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Taken together, these results represent the first full characterization of an Auger-emitting PARP inhibitor which demonstrate a survival benefit in mouse models of GBM and confirm the high potential of 123I-MAPi for clinical translation.

Keyphrases

mouse model
early stage
dna damage
light emitting
dna repair
locally advanced
radiation therapy
quantum dots
cancer therapy
radiation induced
fluorescent probe
free survival
squamous cell carcinoma
human health
risk assessment