RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance.

Zuoqin DuJiaqi WuZiqian FengXiaoyu MaTao ZhangXin ShuJin XuLiqun WangMao LuoJianbo Wu

Published in: Biology of sex differences (2022)

Our findings suggest that RAGE-mediated adipose tissue insulin resistance is sex-specific, which is associated with different expression of genes involved in anti-oxidant and browning and insulin-induced AKT phosphorylation.

Keyphrases

insulin resistance
adipose tissue
high fat diet induced
high fat diet
type diabetes
metabolic syndrome
polycystic ovary syndrome
skeletal muscle
high glucose
diabetic rats
glycemic control
signaling pathway
cell proliferation
drug induced
oxidative stress
protein kinase