Tacrolimus concentrations after renal transplantation in a mother-neonate dyad: Maternal, neonatal and breast milk measurements.
Yumiko AkamineNobuhiro FujiyamaHideaki KagayaMitsuru SaitoHiroshi MiuraYukihiro TeradaTsutomu TakahashiShigeru SatohMasatomo MiuraPublished in: Journal of clinical pharmacy and therapeutics (2021)
The maternal and neonatal blood tacrolimus concentrations at birth are equivalent; thus, one must assume that maternal tacrolimus concentrations directly affect the foetus and/or neonate. Tacrolimus is not detectable in the neonate 3 weeks after birth, suggesting that there is minimal transfer through breast milk.