Immunization with anti-Tn immunogen in maternal rats protects against hyperoxia-induced kidney injury in newborn offspring.
Chung-Ming ChenJaulang HwangHsiu-Chu ChouPublished in: Pediatric research (2020)
Hyperoxia increased nuclear factor-κB (NF-κB) activity and collagen deposition in neonatal rat kidney. Maternal Tn immunization reduced kidney injury as well as collagen deposition in neonatal rats. Maternal Tn immunization reduced kidney injury and was associated with a reduction in 8-hydroxy-2'-deoxyguanosine and NF-κB activity. Tn vaccine can be a promising treatment modality against hyperoxia-induced kidney injury in neonates.
Keyphrases
- nuclear factor
- toll like receptor
- birth weight
- diabetic rats
- oxidative stress
- high glucose
- pregnancy outcomes
- signaling pathway
- lps induced
- inflammatory response
- type diabetes
- weight gain
- weight loss
- adipose tissue
- metabolic syndrome
- pregnant women
- gestational age
- skeletal muscle
- low birth weight
- preterm birth
- replacement therapy