Paramagnetic rim lesions lead to pronounced diffuse periplaque white matter damage in multiple sclerosis.

Nik KrajncVictor SchmidbauerJoel LeinkaufLukas HaiderGabriel BstehGregor KasprianFritz LeutmezerBarbara Kornek Paulus Stefan Rommer Thomas BergerHans LassmannAssunta Dal-BiancoSimon Hametner

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)

PRLs are more destructive than SILs, leading to diffuse periplaque white matter (WM) damage. The quantitative MRI-based evaluation of the PRL PPA could be a marker for silent progression in pwMS.

Keyphrases

white matter
multiple sclerosis
oxidative stress
low grade
magnetic resonance imaging
contrast enhanced
diffusion weighted imaging
computed tomography