Hypoganglionosis in the gastric antrum causes delayed gastric emptying.

Corey BakerMinhal AhmedKatarina ChengEmily ArcieroSukhada BhaveWing Lam N HoAllan M GoldsteinRyo Hotta

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

Older mice exhibit delayed gastric emptying associated with hypoganglionosis and a reduction in nNOS-expressing neurons in the antrum. The causal relationship between antral hypoganglionosis and delayed gastric emptying was verified using a novel experimental model of ENS ablation. This study provides new information regarding the pathogenesis of delayed gastric emptying and provides a robust model system to study this disease and develop novel treatments.

Keyphrases

healthcare
physical activity
nitric oxide
spinal cord injury
metabolic syndrome
adipose tissue
middle aged
social media
insulin resistance