Antibacterial and mechanism of action studies of boxazomycin A.
Sheo B SinghJames OcciJohn OndeykaJohn F BarrettPrakash MasurekarMary MotylCharles GillGino SalituroPublished in: The Journal of antibiotics (2024)
Boxazomycins A-C are potent broad-spectrum antibiotics isolated from Actinomycetes strain G495-1 in 1987. We now report that boxazomycin A inhibits bacterial growth by selectively inhibiting protein synthesis, its effect is bacteriostatic, and it is equally active against drug resistant bacterial strains. No cross-resistance to protein synthesis inhibitors was observed suggesting that its inhibition is distinct from clinical protein synthesis inhibitors. We also report in vivo efficacy in a Staphylococcus aureus murine infection model supported by corresponding pharmacokinetic studies.