Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma.
Nicholas D KlemenSinchun HwangMartina BradicEvan RosenbaumMark A DicksonMrinal M GounderCiara M KellyMary L KeohanSujana MovvaKatherine A ThorntonPing ChiBenjamin A NacevJason E ChanMadalyn G NeuwirthAllison L RichardsSamuel SingerMark T A DonoghueWilliam D TapSandra P D'AngeloPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
In patients with advanced sarcoma, PD-1 blockade can mediate durable responses. HPD occurs in sarcoma at an incidence that is similar to what has been reported in other solid tumors, but patients with HPD were clinically and biologically similar to those who had PD. Further research is required to establish whether HPD is a biologically distinct phenomenon and whether a theoretical risk of HPD should influence patient management.