Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.
Roberto BizzottoChristopher JennisonAngus G JonesAzra KurbasicAndrea TuraGwen KennedyJimmy D BellE Louise ThomasGary S FrostRebeca EriksenRobert Wilhelm KoivulaSoren BrageJane KayeAndrew T HattersleyAlison HeggieDonna McEvoyLeen M 't HartJoline Wilhelma Johanna BeulensPetra EldersPetra B MusholtMartin RidderstråleTue H HansenKristine Højgaard AllinTorben HansenHenrik VestergaardAgnete T LundgaardHenrik S ThomsenFederico De MasiKonstantinos D TsirigosSøren BrunakAna ViñuelaAnubha MahajanTimothy James McDonaldTarja KokkolaIan M ForgieGiuseppe N GiordanoImre PavoHartmut RuettenEmmanouil DermitzakisMark I McCarthyOluf PedersenJochen M SchwenkJerzy AdamskiPaul W FranksMark WalkerEwan R PearsonAndrea Marinull nullPublished in: Diabetes care (2020)
Deteriorating insulin sensitivity and β-cell function, increasing insulin clearance, high visceral or liver fat, and worsening of the lipid profile are the crucial factors mediating glycemic deterioration of patients with T2D in the initial phase of the disease. Stabilization of a single trait among insulin sensitivity, β-cell function, and insulin clearance may be relevant to prevent progression.