Oxidative stress parameters and keap 1 variants in T2DM: Association with T2DM, diabetic neuropathy, diabetic retinopathy, and obesity.
Farnaz KhaliliAsad Vaisi-RayganiEbrahim ShakibaMaryam KohsariMaryam DehbaniRozita NaseriSoheila AsadiZiba RahimiMehrali RahimiZohreh RahimiPublished in: Journal of clinical laboratory analysis (2021)
Our study suggests the role of reduced antioxidant system and Keap1 variants in the pathogenesis of T2DM and its complications of neuropathy and retinopathy and also obesity in enhanced oxidative stress. Monitoring oxidative stress parameters in diabetic patients, especially those with complication and their treatment with antioxidants is suggested.
Keyphrases
- anti inflammatory
- oxidative stress
- diabetic retinopathy
- type diabetes
- insulin resistance
- metabolic syndrome
- weight loss
- dna damage
- diabetic rats
- ischemia reperfusion injury
- copy number
- induced apoptosis
- high fat diet induced
- weight gain
- optical coherence tomography
- glycemic control
- protein protein
- gene expression
- skeletal muscle
- small molecule
- adipose tissue
- dna methylation
- physical activity
- signaling pathway