5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease.

Natalie E ScholpaMary K LynnDaniel CorumHeather A Boger Rick G Schnellmann

Published in: British journal of pharmacology (2017)

These data revealed that LY344864-induced MB attenuates dopaminergic neuron loss and improves behavioural endpoints in this model. We suggest that stimulating MB may be beneficial for the treatment of Parkinson's disease and that the 5-HT1F receptor may be an effective therapeutic target.

Keyphrases

oxidative stress
high glucose
combination therapy
endothelial cells
drug induced
binding protein
data analysis
smoking cessation