WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer.

Eun Ji RoYong-Hee ChoWoo-Jeong JeongJong-Chan ParkDo Sik MinKang-Yell Choi

Published in: Cell communication and signaling : CCS (2019)

In analyses of mice with deletion of Wdr76 and CRC spheroids, we found that RAS stability plays important roles in tumorigenesis by affecting proliferation and CSC activation. Our results suggest that destabilization of RAS by WDR76 is a potential strategy for targeting malignant CRC involving CSC activation.

Keyphrases

wild type
cancer stem cells
signaling pathway
metabolic syndrome
cancer therapy
skeletal muscle
climate change