CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.

Sarah WoelfleDhruva DeshpandeSimone FeldengutHeiko BraakKelly Del TrediciFrancesco RoselliKarl DeisserothJens MichaelisTobias M BoeckersMichael Schoen

Published in: BMC biology (2023)

Taken together, hCLARITY enables research of the human brain with high sensitivity and down to sub-diffraction resolution. It therefore has enormous potential for the investigation of local morphological changes, e.g., in neurodegenerative diseases.

Keyphrases

single molecule
energy transfer
climate change
risk assessment
electron microscopy