Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells.

Weijie GaoYuliang WangShan YuZhu WangTaiyang MaAndrew Man-Lok ChanPeter Ka-Fung ChiuChi-Fai NgDinglan WuFranky Leung Chan

Published in: Stem cell research & therapy (2022)

Enhanced eNOS-NO signaling could function to promote the growth of PCSCs and also the development of metastatic CRPC. Besides eNOS-NO as potential targets, targeting its upstream regulators (ERRα and ERG) of eNOS-NO signaling could also be the therapeutic strategy for the management of advanced prostate cancer, particularly the aggressive cancer carrying with the TMPRSS2:ERG fusion gene.

Keyphrases

nitric oxide synthase
prostate cancer
nitric oxide
endothelial cells
radical prostatectomy
pi k akt
small cell lung cancer
squamous cell carcinoma
genome wide
transcription factor
copy number
climate change
squamous cell
dna methylation
cancer therapy
young adults
genome wide analysis