Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes.

Shinsuke SakaiTakeshi YamamotoYoshitsugu TakabatakeAtsushi TakahashiTomoko Namba-Hamano Satoshi MinamiRyuta FujimuraHiroaki YonishiJun MatsudaAtsushi HesakaIsao MatsuiTaiji MatsusakaFumio NiimuraMotoko YanagitaYoshitaka Isaka

Published in: Journal of the American Society of Nephrology : JASN (2019)

Autophagic activity in PTECs is mainly regulated by insulin. Consequently, autophagic activity differs in types 1 and 2 diabetic nephropathy, which should be considered when developing strategies to treat diabetic nephropathy by modulating autophagy.

Keyphrases

diabetic nephropathy
cell death
type diabetes
signaling pathway
endoplasmic reticulum stress
glycemic control
oxidative stress
metabolic syndrome