Ristocetin dependent cofactor activity in von Willebrand disease diagnosis: Limitations of relying on a single measure.
Pamela A ChristophersonSandra L HaberichterVeronica H FloodUrsula O SickingThomas C AbshireRobert R Montgomerynull nullPublished in: Research and practice in thrombosis and haemostasis (2022)
The diagnosis of VWD based on a single low VWF:RCo but normal VWF:Ag, was often attributed to p.D1472H or variability in VWF:RCo that was eliminated with VWF:GPIbM. Our study suggests that using VWF:RCo alone for diagnostic purposes may be insufficient while repeat VWF:RCo or VWF:GPIbM testing can be valuable in establishing a VWD diagnosis.