A novel homozygous C-terminal deletion in BTG4 causes zygotic cleavage failure and female infertility.

Yufeng WangQingtao QinYang YangShan DongYuting LiuMolin Wang Yong-Xin Zou Yaoqin GongHaibin ZhouBaichun Jiang

Published in: Journal of assisted reproduction and genetics (2022)

This study conforms previous studies and expands the mutational spectrum of BTG4. Our findings prove the functional importance of the C-terminal of BTG4. BTG4 is a potential diagnostic and therapeutic target for patients suffering from zygotic cleavage failure.

Keyphrases

end stage renal disease
ejection fraction
prognostic factors
metabolic syndrome
patient reported outcomes
skeletal muscle
climate change