Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers.

Katia BachaJulien EstagerSylvie Brassart-PascoCatherine ChemottiAntony E FernandesJean-Pierre MbakidiMagali DeleuSandrine Bouquillon

Published in: Polymers (2022)

For this study, new dendrimers were prepared from poly(propylene imine) (PPI) and polyamidoamine (PAMAM) dendrimers using an efficient acid-base reaction with various phenolic acids. The syntheses were also optimized in both microwave and microfluidic reactors. These ionic and hydrophilic dendrimers were fully characterized and showed excellent antioxidant properties. Their cytotoxic properties have been also determined in the case of fibroblast dermal cells.

Keyphrases

oxidative stress
induced apoptosis
anti inflammatory
ionic liquid
cell cycle arrest
high throughput
single cell
circulating tumor cells
endoplasmic reticulum stress
radiofrequency ablation
solid phase extraction