Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain.
Shidan TosifEbene R HaycroftSohinee SarkarZheng Quan TohLien Anh Ha DoCeleste M DonatoKevin J SelvaMonsurul HoqIsabella OvermarsJill NguyenLai-Yang LeeVanessa CliffordAndrew DaleyFrancesa L MordantJodie McVernonKim MulhollandAdrian J MarcatoMiranda Z SmithNigel CurtisSarah McNabRichard SafferyKatherine KedzierskaKanta SubarraoDavid BurgnerAndrew SteerJulie E BinesPhilip SuttonPaul V LicciardiAmy W ChungMelanie R NeelandNigel W CrawfordPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2022)
Utilizing respiratory and nonrespiratory PCR testing, along with the measurement of SARS-CoV-2-specific local and systemic antibodies, provides a more accurate assessment of infection within households and highlights some of the immunological differences in response between children and adults.