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In Vivo Distribution and Therapeutic Efficacy of Radioiodine-Labeled pH-Low Insertion Peptide Variant 3 in a Mouse Model of Breast Cancer.

Min ZhangYue XiHong ChenWangxi HaiBiao Li
Published in: Molecular imaging (2022)
Radioiodine-labeled Var3-pHLIP effectively targeted BC cells in an acidic environment and inhibited the growth of MDA-MB-231 xenografts by ionizing radiation.
Keyphrases
  • cell cycle arrest
  • mouse model
  • induced apoptosis
  • pet imaging
  • cell death
  • cancer therapy
  • breast cancer cells
  • endoplasmic reticulum stress
  • computed tomography
  • signaling pathway
  • cell proliferation