Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression.

Michael WagnerMirna S SadekNataliya DybkovaFleur E MasonJohann KlehrRebecca FirneburgEleder CachorroKurt RichterErik KlapprothStephan R Künzel Kristina LorenzJordi HeijmanDobromir DobrevAli El-Armouche Samuel SossallaSusanne Kämmerer

Published in: International journal of molecular sciences (2021)

Higher PDE2 abundance protects against ISO-induced cardiac arrhythmia by preventing the Epac- and CaMKII-mediated increases of cellular triggers. Thus, activating myocardial PDE2 may represent a novel intracellular anti-arrhythmic therapeutic strategy in HF.

Keyphrases

left ventricular
high glucose
cell proliferation
signaling pathway
diabetic rats
oxidative stress
transcription factor
antibiotic resistance genes