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MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders.

Sarah C BorrieEllen PlasschaertZsuzsanna Callaerts-VeghAkihiko YoshimuraRudi D'HoogeYpe ElgersmaSteven A KushnerEric LegiusHilde Brems
Published in: Molecular autism (2021)
These results demonstrate for the first time that social behavior phenotypes in a mouse model for RASopathies (Spred1-/-) can be acutely reversed. This highlights a key role for Ras-MAPK dysregulation in mediating social behavior phenotypes in mouse models for ASD, suggesting that proper regulation of Ras-MAPK signaling is important for social behavior.
Keyphrases
  • mouse model
  • healthcare
  • mental health
  • signaling pathway
  • pi k akt
  • oxidative stress
  • autism spectrum disorder
  • wild type
  • attention deficit hyperactivity disorder
  • cell proliferation
  • working memory