A re-innervated in vitro skin model of non-histaminergic itch and skin neurogenic inflammation: PAR2-, TRPV1- and TRPA1-agonist induced functionality.
Nicolas LebonvalletJ W FluhrChristelle Le Gall-IanottoR LeschieraM TalagasA ReuxA BatailleC BrunT OddosJ-P PennecJ-L CarréLaurent MiséryPublished in: Skin health and disease (2021)
. We observed that activation of TRPV1, TRPA1 and PAR-2 leads to different response profiles in re-innervated skin explants.