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A re-innervated in vitro skin model of non-histaminergic itch and skin neurogenic inflammation: PAR2-, TRPV1- and TRPA1-agonist induced functionality.

Nicolas LebonvalletJ W FluhrChristelle Le Gall-IanottoR LeschieraM TalagasA ReuxA BatailleC BrunT OddosJ-P PennecJ-L CarréLaurent Miséry
Published in: Skin health and disease (2021)
. We observed that activation of TRPV1, TRPA1 and PAR-2 leads to different response profiles in re-innervated skin explants.
Keyphrases
  • soft tissue
  • wound healing
  • spinal cord injury
  • neuropathic pain
  • oxidative stress
  • high glucose
  • spinal cord
  • endothelial cells