Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1β-GRPR axis.

Xue-Ting LiuYanmei WangYueling ZengDe WangYuhuan WenLimin FanYing HeJunyan ZhangWeimin SunYongping LiuAilin Tao

Published in: Allergy (2023)

neurons through the NLRP3/caspase-1/IL-1β/IL1R1 axis. These results will provide new insights into the pathophysiology of pruritus and novel therapeutic strategies for patients with chronic itch.

Keyphrases

atopic dermatitis
cell death
spinal cord
nlrp inflammasome
neuropathic pain
spinal cord injury
oxidative stress
signaling pathway
induced apoptosis