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Investigating mitochondrial bioenergetics in peripheral blood mononuclear cells of women with childhood maltreatment from post-parturition period to one-year follow-up.

Anja Maria GumppAlexander BehnkeLaura Ramo-FernándezPeter RadermacherHarald GündelUte ZiegenhainAlexander KarabatsiakisIris-Tatjana Kolassa
Published in: Psychological medicine (2022)
This is the first study to longitudinally investigate mitochondrial bioenergetics in postpartum women with and without CM. Our results indicate that CM-related mitochondrial alterations reflect allostatic load, probably due to higher inflammatory states during parturition, which normalize later. However, later inflammatory states might moderate the vulnerability for a second-hit on the level of mitochondrial bioenergetics, at least in immune cells.
Keyphrases
  • oxidative stress
  • climate change
  • young adults