Force-Induced Near-Infrared Chromism of Mechanophore-Linked Polymers.
Qingkai QiGaganjot SekhonRichard ChandradatNnamdi M OfodumTianruo ShenJan ScrimgeourMonu JoyMario WriedtMadhuri JayathirthaCostel C DarieDevon A ShippXiaogang LiuXiaocun LuPublished in: Journal of the American Chemical Society (2021)
A near-infrared (NIR) mechanophore was developed and incorporated into a poly(methyl acrylate) chain to showcase the first force-induced NIR chromism in polymeric materials. This mechanophore, based on benzo[1,3]oxazine (OX) fused with a heptamethine cyanine moiety, exhibited NIR mechanochromism in solution, thin-film, and bulk states. The mechanochemical activity was validated using UV-vis-NIR absorption/fluorescence spectroscopies, gel permeation chromatography (GPC), NMR, and DFT simulations. Our work demonstrates that NIR mechanochromic polymers have considerable potential in mechanical force sensing, damage detection, bioimaging, and biomechanics.
Keyphrases
- drug release
- fluorescent probe
- photodynamic therapy
- single molecule
- fluorescence imaging
- living cells
- drug delivery
- high glucose
- diabetic rats
- oxidative stress
- mass spectrometry
- magnetic resonance
- drug induced
- high resolution
- high speed
- risk assessment
- liquid chromatography
- molecular docking
- hyaluronic acid
- ms ms
- molecular dynamics simulations
- crystal structure
- stress induced
- simultaneous determination
- monte carlo
- sensitive detection