Maternal obesity: sex-specific in utero changes in fetal brain autophagy and mTOR.
Nana MerabovaLierni UgartemendiaAndrea G EdlowClaudia IbarraNune DarbinianGabriel TatevosianLaura GoetzlPublished in: Obesity (Silver Spring, Md.) (2024)
We present novel evidence suggesting that in utero exposure to maternal obesity in humans may significantly affect neurodevelopment, especially in male fetuses, through alterations in normal autophagy molecular mechanisms and with adiponectin as a potential mediator.
Keyphrases
- insulin resistance
- metabolic syndrome
- birth weight
- weight gain
- weight loss
- cell death
- endoplasmic reticulum stress
- high fat diet induced
- type diabetes
- signaling pathway
- gestational age
- pregnancy outcomes
- oxidative stress
- adipose tissue
- skeletal muscle
- resting state
- physical activity
- pregnant women
- cerebral ischemia
- climate change
- risk assessment
- blood brain barrier
- functional connectivity
- subarachnoid hemorrhage