Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory.

Eric J BrunnerKoutatsu MaruyamaMartin ShipleyNoriko CableHiroyasu IsoAyako HiyoshiDaryth StalloneMeena KumariÁdám Gy Tabák Archana Singh-ManouxJohn WilsonClaudia LangenbergNick WarehamDavid BonifaceAroon D Hingorani Mika Kivimaki Clare H Llewellyn

Published in: International journal of obesity (2005) (2021)

Appetite disinhibition is most likely to be a defining characteristic of genetic susceptibility to obesity. High levels of appetite disinhibition, rather than hunger, may underlie genetic vulnerability to obesogenic environments in two-thirds of the population of European ancestry.

Keyphrases

weight loss
genome wide
body weight
copy number
metabolic syndrome
weight gain
body mass index
type diabetes
climate change
insulin resistance
gene expression
adipose tissue
dna methylation
physical activity
skeletal muscle