Progressive medial temporal degeneration with TDP-43 pathology is associated with upper limb and bulbar onset types of amyotrophic lateral sclerosis.
Takahiro TakedaSayuri KokubunYumiko SaitoAtsuko TsuneyamaAi IshikawaSagiri IsoseKimiko ItoKimihito AraiAkihiro KorekiAtsuhiko SugiyamaSatoshi KuwabaraKazuhiro HondaPublished in: Journal of neurology (2022)
Medial temporal atrophy in ALS is associated with bulbar and upper limb onset subtypes. This progression may be related to the extent of TDP-43 pathology.