Naturally occurring 5' preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C.
Jing LiJisu LiShiqi ChenQuan YuanJing ZhangJingwen WuQirong JiangQianru WangNing-Shao XiaJi-Ming ZhangShuping TongPublished in: Gut (2020)
The 15-nt and 18-nt deletions somehow increase HBV RNA, replicative DNA and virion production. Shortened L protein is more efficient at mediating HBV infection.