Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Kareen HeinzeHelen C BarronEmma K HowesMani RamaswamiMatthew R Broome

Published in: The British journal of psychiatry : the journal of mental science (2020)

In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.

Keyphrases

blood brain barrier
autism spectrum disorder
intellectual disability
white matter
resting state
depressive symptoms
risk assessment
subarachnoid hemorrhage