Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study.

Donatella PolettiValeria IanniniPaolo CasolariMarco ContoliAlberto PapiPaul KirkhamTrevor T HanselKian Fan ChungPeter J BarnesAntonio PastoreStefano PelucchiIan M AdcockGaetano Caramori

Published in: Journal of inflammation (London, England) (2016)

Patients with persistent untreated NAR, compared with normal control subjects and patients with persistent NAR under regular treatment with nasal fluticasone furoate by at least 20 days, have more nasal symptoms, worst quality of life and an increased number of nasal inflammatory cells (neutrophils, eosinophils), goblet cells and MUC5AC+ nasal epithelial cells. This nasal inflammation seems unrelated to NF-kB activation.

Keyphrases

chronic rhinosinusitis
oxidative stress
induced apoptosis
allergic rhinitis
cell cycle arrest
signaling pathway
pi k akt
physical activity
depressive symptoms
inflammatory response
cell death