Significance of O6-methyl guanine methyltransferase promoter methylation in high grade glioma patients: optimal cutoff point, CpG locus, and genetic assay.

Murat Buyuktepe Ibrahim Kaplan Eyup Bayatli Haldun Dogan Hasan Caglar Ugur

Published in: Journal of neuro-oncology (2023)

Our outcomes support the prognostic value of MGMT promoter methylation in patients with high grade glioma. Sequencing of whole promoter CpG islands demonstrated that methylation of particular CpG sites might predict clinical outcomes more precisely.

Keyphrases

dna methylation
high grade
genome wide
gene expression
low grade
end stage renal disease
copy number
ejection fraction
chronic kidney disease
transcription factor
peritoneal dialysis
type diabetes
single cell
skeletal muscle
patient reported outcomes