Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia.

Alessia Roma Matthew Tcheng Nawaz Ahmed Sarah Walker Preethi Jayanth Mark D Minden Kristin J Hope Praveen P N Rao Jessica Luc Andrew Charles Doxey Julie A Reisz Rachel Culp-Hill Angelo D'Alessandro Paul A Spagnuolo

Published in: Molecular cancer research : MCR (2022)

This work highlights the effects of direct CII inhibition in mediating selective AML cell death and provides insights into glutamine anaplerosis as a metabolic adaptation that can be therapeutically targeted.

Keyphrases

cell death
cancer therapy
cell proliferation
cell cycle arrest
allogeneic hematopoietic stem cell transplantation