Investigations of the novel checkpoint kinase 1 inhibitor SRA737 in non-small cell lung cancer and colorectal cancer cells of differing tumour protein 53 gene status.

Ali Jn DuabilChristian R CooperEsraa AldujailySarah Er HalfordSandra HirschbergSidath D Katugampola George D D Jones

Published in: Exploration of targeted anti-tumor therapy (2023)

This study's data suggests that P53 status/functioning is a key factor in determining the sensitivity of NSCLC and CRC cancer cells towards CHK1 inhibition, even in circumstances conducive to high replicative stress.

Keyphrases

small cell lung cancer
dna damage
copy number
cell cycle
electronic health record
genome wide
big data
cell proliferation
gene expression
binding protein
transcription factor
data analysis