Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations.

Aroon T ChandeLavanya RishishwarAndrew B ConleyAugusto Valderrama-AguirreMiguel A Medina-RivasI King Jordan

Published in: BMC medical genetics (2020)

T2D associations that replicate across populations provide for more reliable risk inference, and modeling population-specific frequencies of ancestral and derived risk alleles can help control for biases in PRS estimation.

Keyphrases

type diabetes
cardiovascular disease
gene expression
african american
copy number