Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders.

Zuxing WangXiandong LinXinqun LuoJun XiaoYong ZhangJianying XuShibin WangFen ZhaoHuifen WangHangxiao ZhengWei ZhangChen LinZewen TanLiping CaoZhiren WangYunlong TanWenzhong ChenYuping CaoXiaoyun GuoChristopher PittengerXingguang Luo

Published in: Schizophrenia bulletin (2023)

Integrating multiple levels of analyses, we identified CACNA1C variants associated with multiple psychiatric disorders, and schizophrenia and bipolar disorder were most strongly implicated. CACNA1C variants may contribute to shared risk and pathophysiology in these conditions.

Keyphrases

bipolar disorder
copy number
major depressive disorder
gene expression
genome wide