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Recombinant IFN-γ1b Treatment in a Patient with Inherited IFN-γ Deficiency.

Jérémie RosainAyça KiykimAlexandre MichevYasemin Kendir DemirkolDarawan RinchaiJessica N PeelHailun LiSuheyla OcakPinar Gokmirza OzdemirTom Le VoyerQuentin PhilippotTaushif KhanAnna-Lena NeehusMélanie MigaudCamille SoudéeStéphanie Boisson-DupuisNico MarrAlessandro BorghesiJean Laurent CasanovaJacinta Bustamante
Published in: Journal of clinical immunology (2024)
We describe a patient with a new form of autosomal recessive IFN-γ deficiency, with intracellular, but not extracellular IFN-γ. IFN-γ1b treatment appears to have been beneficial in this patient, with no recurrence of mycobacterial infection over a period of more than 30 months. This targeted treatment provides an alternative to HCST in patients with complete IFN-γ deficiency or at least an option to better control mycobacterial infection prior to HCST.
Keyphrases
  • immune response
  • dendritic cells
  • case report
  • mycobacterium tuberculosis
  • replacement therapy
  • drug delivery
  • reactive oxygen species
  • smoking cessation
  • duchenne muscular dystrophy
  • free survival