Genomic landscape and clinical features of advanced thyroid carcinoma: a national database study in Japan.

Soji TodaYukihiko HiroshimaHiroyuki IwasakiKatsuhiko Masudo

Published in: The Journal of clinical endocrinology and metabolism (2024)

Genetic abnormalities with treatment options were found in 62.7% of advanced thyroid carcinomas. TP53 abnormality was an independent poor prognostic factor for overall survival in differentiated thyroid carcinoma. The time to treatment failure for lenvatinib was not different based on genetic profile.

Keyphrases

prognostic factors
copy number
genome wide
quality improvement
high grade
single cell
gene expression
combination therapy
drug induced