Protective effect of proton-pump inhibitor against gastrointestinal bleeding in patients receiving oral anticoagulants: A systematic review and meta-analysis.

Hyo-Jeong AhnSo-Ryoung LeeEue-Keun ChoiTae-Min RheeSoonil KwonSeil OhGregory Y H Lip

Published in: British journal of clinical pharmacology (2022)

In patients who receive OAC, PPI cotherapy is associated with a lower total and major GIB irrespective of ethnic group and OAC type, except for edoxaban. PPI cotherapy can be considered particularly in patients with high risk of GIB.

Keyphrases

oral anticoagulants
protein protein
atrial fibrillation
small molecule
venous thromboembolism