Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants.
André B P van KuilenburgMarjolein C H Pleunis-van EmpelRick B BrouwerAngelique E J SijbenDaan G KnapenThijs H Oude MunninkJelmer J van ZandenJenny Janssens-PuisterDoreen DobritzschRutger MeinsmaJudith Meijer-JansenSilvy J M van DoorenRaymon VijzelaarAna PopGajja S SalomonsJan Gerard MaringKlary E Niezen-KoningPublished in: JCO precision oncology (2024)
A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.