METTL3 (Methyltransferase Like 3)-Dependent N6-Methyladenosine Modification on Braf mRNA Promotes Macrophage Inflammatory Response and Atherosclerosis in Mice.
Qian LiLiwen YuAmy GaoRuiqing RenJianlin ZhangLei CaoXiaohong WangYapeng LiuWenqian QiLiangyu CaiWei LiWeiwei WangXiaobin GuoGuohai SuXiao YuJie ZhangBo XiYun ZhangMeng ZhangCheng ZhangPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
mRNA as a novel target of METTL3 in the activation of the ox-LDL-induced ERK pathway and inflammatory response in macrophages. METTL3 may represent a potential target for the treatment of atherosclerosis.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- cardiovascular disease
- toll like receptor
- signaling pathway
- binding protein
- cell proliferation
- diabetic rats
- pi k akt
- high fat diet induced
- type diabetes
- risk assessment
- metabolic syndrome
- oxidative stress
- human health
- combination therapy
- insulin resistance
- metastatic colorectal cancer
- endothelial cells