A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in Brazil.

Léa C CastellucciLucas AlmeidaSvetlana CherlinMichaela FakiolaRichard W FrancisEdgar M CarvalhoAnadílton Santos da HoraTainã Souza do LagoAmanda B FigueiredoClara M CavalcantiNatalia S AlvesKatia L P MoraisAndréa Teixeira-CarvalhoWalderez O DutraKenneth J GollobHeather J CordellJenefer M Blackwell

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

This first GWAS for CL identified multiple genetic risk loci including a novel lead to understanding CL pathogenesis through regulation of interferon-γ by IFNG antisense RNA 1.

Keyphrases

genome wide association study
genome wide
dna methylation
gene expression
dendritic cells
copy number