Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study.

Louise A DonnellyJohn M DennisRuth L Coleman Naveed Sattar Andrew T Hattersley Rury R Holman Ewan R Pearson

Published in: Diabetes care (2020)

Metformin use is associated with early risk of anemia in individuals with type 2 diabetes, a finding consistent across two RCTs and replicated in one real-world study. The mechanism for this early fall in hemoglobin is uncertain, but given the time course, is unlikely to be due to vitamin B12 deficiency alone.

Keyphrases

type diabetes
cardiovascular disease
adipose tissue
metabolic syndrome
iron deficiency
insulin resistance